BioDefense
Food Security Testing
Water Security Testing
Mutation Discovery
  - LightScanner
  - LightScanner 32
  - LightScanner Master Mixes
  - LCGreen Plus Melting Dye
  - LightScanner Assays
  - Custom Probes & Primers
  - Reagents, Buffers & Capillary Tubes
Genotyping
FilmArray
Mutation Discovery

Mutations in PCR products are detected by the presence of heteroduplexes optimally detected by our LCGreen® Plus dye. Variations are identified by changes in the shape of the melting profile compared to a reference sample. Hi-Res Melting® on the LightScanner® is also being used for mutation discovery in tumor samples, yielding information on mutations present in low allele fractions (as low as 5%) and allelic imbalances between tumor and matched normal samples.

Use the links below to learn more about our complete line of mutation discovery products.

 
Instrument

LightScanner Instrument
LightScanner® System

  • Hi-Res Melting Instrument
  • 96- or 384-well plate system
  • Results in less than 5 minutes
  • Software automatically analyzes each sample and defines the standards and variants

LightScanner 32 System
LightScanner 32 System

  • Hi-Res Melting Instrument
  • 32-sample carousel
  • Analysis time less than 30 minutes
  • Highly optimized for LCGreen Plus
Chemistry

LightScanner Master Mix
LightScanner Master Mix

  • A pre-optimized solution
    specifically designed to deliver superior PCR performance for Hi-Res Melting applications on the LightScanner Instrument.

LightScanner Master Mix
Genotyping Master Mix

  • A pre-optimized Master Mix specially designed for genotyping experiments not requiring an enzyme with exonuclease activity.

High Sensitivity Master Mix
High Sensitivity Master Mix

  • The LightScanner® High Sensitivity Master Mix is a specialized master mix containing LCGreen Plus® dye and internal temperature calibrators.

Warfarin Genotyping Reagents
Warfarin Genotyping Reagents

  • Our Warfarin Genotyping Reagents (ASR) provide a fast and effective solution for genotyping.

LCGreen + Melting Dye
LCGreen® Plus+ Melting Dye

  • LCGreen dye is specifically designed for Hi-Res Melting curve analysis to detect DNA sequence variants (mutations, polymorphisms, etc).

LCGreen + Melting Dye
Reagents, Buffers and Capillary Tubes
Services

LightScanner Assay Protocols
LightScanner Assays

  • Free assay design protocols that have been optimized for Hi-Res Melting.

IT BioChem - Custom Probes, Primers and Melting Dyes
Custom Probes & Primers

  • Order custom designed probes, primers and melting dyes for DNA amplificaiton, mutation and detection.
  • ASR grade oligos.
  • Manufactured under cGMP.